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Kalpana Luthra

Dr. Kalpana Luthra is a Professor in the Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India. She completed her PhD at AIIMS in 1994 and joined as faculty at AIIMS in 1998. She was awarded the Fogarty fellowship in 2002 and availed training in HIV-1 antibody related work at New York University. Dr.Luthra is a recipient of Shakuntala Amir Chand Prize awarded by Indian Council of Medical Research (ICMR) for the year 2003. She is a recipient of the FAIMER (Foundation of Advanced International Medical Education and Research) fellowship in year 2006.

The major focus of her work has been towards understanding the co-evolution of virus and antibody responses in HIV-1 infected individuals, generation of human anti-HIV-1 recombinant monoclonal antibodies as potential therapeutic reagents against HIV-1 and to map the neutralization determinants on the HIV-1C to identify Indian clade C specific epitopes for immunogen design. She is actively involved in ongoing national and international collaborative research projects in this area of research.

Recently, her research group successfully generated an anti-HIV-1 broadly neutralizing antibody from an Indian pediatric elite neutralizer. This antibody is being further characterized to evaluate its potential as an anti-HIV-1 reagent. Further her team has shown that distinct circulating viruses in chronic HIV-1 infected children are  associated with maintenance of elite neutralizing activity in chronically HIV-1 clade C infected monozygotic pediatric twins. Her study on circulating HIV-1 in perinatally infected infants defined viral factors associated with early bnAb responses, supportive of polyvalent vaccination approaches capable of inducing bnAbs against HIV-1 (Nat.Commun.,2020)